Luxury Cruise Lines In The Mediterranean This 2025

santorini greece oia sunset island village

As a destination, the Mediterranean is an obvious choice for luxury travelers. Home to gorgeous beaches, rich history, outstanding cuisine, and timeless culture, the Mediterranean is sure to delight curious travelers looking for a unique vacation experience. When it comes to luxury cruise lines in the Mediterranean in 2025, there are various itinerary choices, outstanding amenities, and shore excursions to choose from. 

From the natural beauty of the Greek Isles to the history of Istanbul, the Mediterranean has many adventures in store for those ready to get out and find them. Whether you’re interested in ancient history or are more interested in tasting your way across one of the world’s most renowned culinary regions, a Mediterranean cruise has a little bit of everything on the menu. As expert travel advisors we cannot recommend this destination enough, so let’s take a deep dive into what one can expect from luxury cruise lines in the Mediterranean in 2025. 

luxury cruise lines in the Mediterranean 2025

Best Luxury Cruise Lines In The Mediterranean In 2025

Azamara is a luxury cruise provider with a number of interesting and exciting Mediterranean cruise itineraries to choose from. 

From World Voyages to specialized Mediterranean cruises, this is one of our top luxury cruise lines in the Mediterranean. 

Those looking to experience Greece and its spectacular islands can do so with Azamara on their Greece Intensive Voyage. On a roundtrip cruise from Athens, notable ports of call include Mykonos, Santorini, Rhodes, and Crete. 

Known for its destination-focused approach to high-end cruising, Azamara Cruises provides guests with a deeper level of immersion thanks to their carefully curated shore excursions and activities. 

Seabourn is another luxury cruise line that’s mastered the art of the Mediterranean cruise vacation. Their Adriatic Gems & Greece itinerary brings guests from the canals of Venice along the Adriatic Sea with calls on Corfu, Dubrovnik, Brindisi, Piraeus (Athens), and more – all while providing the unmatched service and amenities Seabourn Cruises is known for.  

Oceania Cruises has a number of luxury Mediterranean cruises available as well. Their Italy & Ancient Isles itinerary leaves from Rome on its way to Istanbul, stopping at Salerno, Palermo and Valletta in Italy, to continue touring the azure waters on its way to Turkey.

Viking Cruises has long been considered a top luxury cruise line and their Mediterranean cruises are second to none. For those looking to delve deeper into the history of the region, Viking’s Ancient Mediterranean Treasures itinerary departs from historic Istanbul and brings guests to some of the most important places in Greek mythology; the islands of Crete and Rhodes. It ends in Athens where guests can extend their vacation to see more of the city. 

Scenic Cruises‘ spectacular yachts, make it one of our top luxury cruise lines in the Mediterranean this 2025. Their seven nights Mediterranean escapade leaves from Barcelona and travels all around the beautiful bays of the Costa Brava, to spend the rest of the voyage exploring the French Riviera in all inclusive luxury.

Regent Seven Seas is a luxury Mediterranean cruises specialist, with a number of exquisite ships to choose from. Known for its attention to detail when it comes to itineraries, cuisine, and onboard amenities, Regent Seven Seas is a top option for those booking luxury cruises to the Mediterranean.  

Take on a 10-night voyage departing from Athens, and head on to explore the Mediterranean coast of Izmir, Turkey, to then take on an indulgent journey across the shores of Italy, passing through Tuscany, Sicily, and Rome, to end the trip in the lavish Monte Carlo with an overnight stay. 

Eager to try something new? We invite you then to get on board the Ritz-Carlton Yacht Collection, redefining the experience when it comes to luxury cruise lines in the Mediterranean. Their newly released yachts are purposefully designed to take you where bigger ships cannot go, evoking a relaxed freedom yachting aficionados are used to. 

greece rhodes lindos acropolis ancient

Featuring the same high level of service Ritz-Carlton guests have come to expect, personalized attention and luxurious amenities onboard are guaranteed, while each spacious suite features a private terrace from where to absorb each destination. 

Itineraries onboard the Evrima yacht drop anchor in the Greek Isles, Balearic Islands, and French Riviera, providing overnights at destinations such as Casablanca, Seville, Dubrovnik, and Monte Carlo. 

As top planners of luxury Mediterranean cruise vacations, we make sure to take care of every aspect of the process from research and planning to making sure your needs are met in every step of the journey. 

Stay in touch with all the latest Mediterranean cruise vacation news and itineraries when you sign up for the Luxury Cruise Connections email newsletter. It’s the easiest way to stay up to date with the best cruises coming right to your inbox!  

diego riveron
Diego Riveron
Sr. Luxury Cruise & Travel Specialist at Luxury Cruise Connections | + posts

My passion for travel started at a very young age, with a curiosity to learn about different cultures. After taking my first cruise at age 12, I have had a love affair with the ocean, having set sail in over 50 cruises around the globe.

As an expert on luxury cruising and travel with over 25 years of experience in the airline and cruise industry, I can assist you in booking the vacation of your dreams.

A Virtuoso Travel Icon, my expertise and contact base are the key to helping you choose the best itinerary based on the luxury experience you want. 

Contact me directly at diego@luxurycruiseconnections.com / +1 786-628-1135